Maggie's own white trash family cares little for her well-being. Maggie saves up enough of her winnings to buy her mother a house, but instead of being grateful, she berates Maggie for endangering her welfare payments and Medicaid benefits. She also belittles her daughter's success in the ring, saying that everyone back home is laughing at her.
Frankie is finally willing to arrange a title fight. He secures Maggie a $1 million match in Las Vegas against the WBA women's welterweight champion, Billie "The Blue Bear", a German ex-prostitute who has a reputation as a dirty fighter. Overcoming a shaky start, Maggie begins to dominate the fight, but after a round has ended, Billie knocks her out with a sucker punch from behind. Before Frankie can pull a stool out of the way, Maggie lands hard on it, breaking her neck and leaving her a quadriplegic.
At first, Frankie refuses to accept the bleak prognosis, but dozens of other medical opinions unanimously confirm there is no hope of recovery. He half-heartedly places the responsibility on Scrap for convincing him to train Maggie, but in the end blames himself.
In a medical rehabilitation facility, Maggie looks forward to a visit from her family, though Frankie repeatedly calls them with no success. Eventually, the family arrives—but only after first visiting Disneyland and Universal Studios Hollywood -- and with an attorney in tow. Their lone concern is to arrange the transfer of Maggie's assets to them. She sees through their transparent scheme and orders them to leave, threatening to sell the house, which they have not claimed in their name to continue receiving welfare payments, out from under them if they ever show their faces again.
Frankie never leaves her side. He reads to her, urges her to go back to school and invites her to come live with him. As the days pass, though, Maggie develops bedsores and undergoes an amputation for an infected leg. She asks a favor of Frankie: to help her die while she can still remember the cheers she heard, saying she got what she most wanted out of life.
A horrified Frankie refuses, but seeks the advice of his priest, Father Horvak, whom he has tormented for 23 years. Horvak warns him that euthanasia is a grave sin, and that he will be lost forever if he goes through with it. Maggie bites her tongue repeatedly in an attempt to bleed to death, but the medical staff saves her life and takes measures to prevent further suicide attempts.
Frankie sneaks in one night. Just before administering a fatal injection of adrenaline, he finally tells Maggie the meaning of a nickname he gave her, Mo Chuisle (spelled incorrectly in the film as "mo cuishle"): Irish for "my darling, and my blood" (literally, "my pulse"). He then disappears for good. Scrap's narration is revealed to be a letter to Frankie's daughter, Katy, informing her of her father's true character.
